ea0070aep346 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020
Zhu Zhenzhen
, Fan Cuili
, Zhu Shanwei
, Wang Lizhen
, Cai Fei
, Gao Xian
, Zhang Li
, Tang Xiaolu
, Liu Hongli
, Wei Zhenman
Bile acids (BAs) are synthesized by converting cholesterol in hepatocytes and recycling it via enterohepatic circulation. Most BAs are reabsorbed into hepatocytes, where they inhibit their own synthesis by activating FXR pathway. NTCP is a major transporter of BAs via absorption from portal blood into hepatocytes. Hepalatide is a 47aa synthetic peptide that specifically binds NTCP resulting in BA spillover of hepatocytes into the systemic circulation. In this way, BA synthesis...